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"Combination Therapy Eases Pulmonary Arterial Hypertension"


Source: CBC.CA

Published: 01 Dec 2021

Category: Pharmaceutical

Rating: (2 stars)

what they said (Hover the mouse cursor over underlined words for more info)

A combination therapy of two drugs - inhaled iloprost and bosentan - appears to improve the condition of patients with pulmonary arterial hypertension (PAH), a debilitating and potentially fatal disease characterized by a progressive narrowing of blood vessels in the lungs.

Dr. Vallerie V. McLaughlin, of the University of Michigan Medical Center, and nine colleagues studied 65 PAH patients who were being treated with bosentan, an endothelin receptor antagonist that helps boost blood flow in the lungs.

Of those patients, 32 were selected to receive inhaled iloprost (a prostacyclin analog) along with bosentan, while the remainder took a placebo and bosentan...

The original article can be found at:

how did it rate? (more information)

Criteria Rating
Total Score 4 of 10
Availability of Treatment Not Satisfactory (?)
Novelty of Treatment Satisfactory (?)
Disease Mongering Satisfactory (?)
Treatment Options Not Satisfactory (?)
Costs of Treatment Not Satisfactory (?)
Evidence Satisfactory (?)
Quantification of Benefits of Treatment Satisfactory (?)
Harms of Treatment Not Satisfactory (?)
Sources of Information Not Satisfactory (?)
Relies on Press Release Not Applicable
Quantification of Harms of Treatment Not Satisfactory (?)

what we said (Hover the mouse cursor over underlined words for more info)

One has to ask if being able to walk 98 feet further during a six-minute walk test represents a significant improvement? This very short report would have benefited from some sense of how patients with pulmonary arterial hypertension (PAH) typically do -even though it says they 'grow worse over time' and whether there are adverse effects of the treatment. One sentence telling us if it is available and what it costs would have fit into a short story of this length.

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