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"Colon cancer drug Avastin linked to esophagus problem"


Source: CBC.CA

Published: 12 Jun 2022

Category: Pharmaceutical

Rating: (0 stars)

what they said (Hover the mouse cursor over underlined words for more info)

An advisory has been issued after the colorectal cancer drug Avastin was linked to the development of a rare, potentially fatal problem with the esophagus.
Health Canada approved the use of Avastin or bevacizumab, in combination with other drugs, to extend the lives of people with colorectal cancer that has spread to other sites.
In an advisory Tuesday, the department said use of Avastin and other cancer treatments has been linked with the development of tracheo-esophageal fistulas - abnormal connections between the esophagus (the tube from the throat to stomach) and the trachea (the windpipe), which normally remain separate.

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how did it rate? (more information)

Criteria Rating
Total Score 0 of 0
Availability of Treatment Not Applicable
Novelty of Treatment Not Applicable
Disease Mongering Not Applicable
Treatment Options Not Applicable
Costs of Treatment Not Applicable
Evidence Not Applicable
Quantification of Benefits of Treatment Not Applicable
Harms of Treatment Not Applicable
Sources of Information Not Applicable
Relies on Press Release Not Applicable
Quantification of Harms of Treatment Not Applicable

what we said (Hover the mouse cursor over underlined words for more info)

The symptoms and warning about tracheo-esophageal fistulas associated with bevacizumab are described well. But, not including the number of patients who did not have significant adverse events, or the evidence on the successful treatment of colon cancer compared to other treatment options. This prevents the reader from assessing whether the "potentially fatal" adverse events with bevacizumab are worth the risk.

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